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Emerging research also suggests that cardiovascular dysfunction—especially orthostatic hypotension and cardiac denervation—contributes to early mortality (Grosu et al., 2023)
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Igf1 CART-KO presented less staining of the cartilage degrading enzymes matrix metalloproteinase 13 (MMP13) and a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) compared to control mice upon CHIR intra-articular injections (Supplementary Fig
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