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In comparison, there is less of a decrease in the CL of apixaban from advanced kidney disease, and after studies on the basis of core pharmacokinetic principles, an appropriate dose reduction was determined and tested (5), providing guidance for its use in patients who are dialysis dependent (22)
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Despite studies indicating that it had the potential to rescue various p53 missense mutants [38, 39], many studies, including this one, have suggested otherwise
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