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GrimAge results not included) Participants were metabolically healthy at baseline, undermining the “metabolic dysfunction” narrative Impossible to attribute effects to any specific intervention The Evidence Landscape This review found the protocol components span from high-quality evidence to no evidence at all: Strong evidence: Speed-of-processing cognitive training (ACTIVE trial: 29% dementia risk reduction), Mediterranean diet (HR 0.70 for AD) Moderate evidence for specific populations: Exercise in MCI (but harmful in established dementia), B vitamins for elevated homocysteine (but only with adequate omega-3), omega-3s in MCI (but not AD), ketogenic diet, probiotics Null or negative evidence: CPAP for cognition (despite strong sleep apnea-dementia association), vitamin D supplementation (despite strong observational links), late-life hormone replacement (increased dementia risk), testosterone replacement (no cognitive benefit despite observational associations), valacyclovir (worsened outcomes), chelation, DHEA No evidence: Low-dose naltrexone, liposomal glutathione, many nootropic supplements in the ReCODE stack

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They do allow for posting comments and questions, which I do my best to respond to