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Contexto histórico y estructural: Monnier et al., 1975, Pflügers Archiv · PMID 1237876 · Schoenenberger et al., 1978, Pflügers Archiv · PMID 568769 02Sistemas experimentales y límites Las nueve fuentes no establecen un receptor único ni un mecanismo uniforme para DSIP

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62-65% of pregnant women use acetaminophen during pregnancy • By 9 months of age: Up to 95% of children have been exposed to acetaminophen NEURODEVELOPMENTAL DISORDER PREVALENCE TIMELINE[⁹⁰⁻⁹⁹] • 1960s: Prevalence estimated at 1 in 10,000 • 1980s: Prevalence rises to 1 in 2,000 • Late 1980s-1990s: Rates begin dramatic increase • Late 1990s: Prevalence reaches 1 in 200 • 1996-2010: 269% increase in ASD prevalence (Atlanta surveillance data) • 2021: Prevalence reaches 1 in 44 in the United States • 1998-2018: 787% increase in recorded incidence in the UK THE TEMPORAL PATTERN The dramatic rise began in the late 1980s and accelerated through the 1990s and 2000s—approximately 25-30 years after acetaminophen’s introduction and widespread adoption in pregnancy, and coinciding with increased use for post-vaccination symptom management in infants

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