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The FOXO4 peptide in a DRI conformation (D-amino acids in a retro-reversed sequence), henceforth named FOXO4-DRI, competes with FOXO4 for p53 binding in a dose-dependent manner and doing so with higher affinity.
This means a single vial can be used for multiple withdrawals over up to 28 days after first puncture, making it far more practical and cost-effective for research settings where multiple reconstitutions are needed
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Thereby, prototype cytoprotective agent gastric pentadecapeptide BPC 157, which has been used in trials for ulcerative colitis and now for multiple sclerosis, would rescue IC lesions in rats (IC rats)
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