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Most preclinical anti-emetic drug discovery research has focused on mechanisms involving cisplatin, with a view that it is the most emetogenic of the agents used, and if an agent reduces emesis to this anti-cancer drug, it should be also successful to reduce nausea and emesis resulting from the lower-risk treatments ( TABLE 4 Classification of chemotherapeutic agents according to their emetogenicity
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World Scientific, 2009
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