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The induction of the MPT subsequent to APAP overdose results in breakdown of the proton gradient across the membrane, loss of mitochondrial membrane potential, and consequently, cessation of ATP production, which eventually leads to cell death [94-97]
adrenal-stress
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Cuprizone-brain damage and motoric disability Cuprizone 2.5% of diet regimen was combined with BPC 157 in drinking water 10 ยตg/kg or 10 ng/kg, 0.16 ยตg/ml/12 ml/day or 0.16 ng/ml/12 ml/day till the sacrifice after four days, with the additional applications once daily, last application at 24 hours before sacrifice: cuprizone 1 g/kg intragastrically while BPC 157 was given 10 ยตg/kg or 10 ng/kg intragastrically, controls received intragastrically an equivolume (5 ml/kg) of saline
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