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In the event of severe AEs, urgent medical attention will be provided, the study intervention will be discontinued, and the research ethics committee will be notified within 24 h with a detailed report outlining the nature of the event, actions taken, and outcomes
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CHAOS trial demonstrated that α-tocopherol is able to reduce the incidence of myocardial infarction, however, failed to reduce the mortality in cardiovascular diseases (Stephens et al
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