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Hyperglycemia and hypoglycemia are both contributors to BBB dysfunction in infarct regions after reperfusion, mediated by elevations in the expression of MMP-2/-9 and decrease of TJ proteins including occludin, claudin-5, and ZO-1 ( Blood–Brain Barrier Permeability in the Acute Phase of Stroke and Its Implication on Hemorrhagic Transformation After the first six hyperacute hours and during the next 72/96 h, the acute stage of stroke will take place
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