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14 Of the remaining acetaminophen, approximately 2% is excreted unchanged in the urine and the rest undergoes CYP450-mediated oxidation to form a reactive metabolite, N -acetyl- p -benzoquinone imine (NAPQI)
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Serum thioredoxin reductase is highly increased in mice with hepatocellular carcinoma and its activity is restrained by several mechanisms
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