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10.1126/science.1254445 Science 89 MaJ.Sanchez-DuffhuesG.GoumansM
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The superior reductions in HbA1c and body weight observed with CagriSema align with mechanistic expectations, as the combination targets both the GLP-1 and amylin pathways.22 The weight loss effects from the NMA appear large compared to prior trials, suggesting potential overestimation due to indirect evidence or small-study bias
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