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Following GPx-mediated H 2 O 2 consumption, residual hydrogen peroxide undergoes Fenton-type redox reactions with Fe 2+ ions, generating Fe³ + species that coordinate with Tiron through catechol moieties to form a stable ferri-Tiron complex [Fe(C 6 H 4 Na 2 O 8 S 2 )]³ +
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5 Novel revelations regarding cell death mechanisms in discrete nuclei affected in PD, notably within critical centers like the respiratory system Current understanding about the role of cell death in Parkinson’s disease is due to neurodegeneration in midbrain, notably within the SN
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