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[DOI] [PMC free article] [PubMed] [Google Scholar] 130.Briani C., Dalla Torre C., Citton V., Manara R., Pompanin S., Binotto G., Adami F
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In breast cancer, PIK3CA mutations direct Hcy flux towards TSS to meet cellular cysteine demands, as these mutants transcriptionally suppress xCT expression and inhibit xCT activity via mTORC2-mediated phosphorylation [77–78]
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