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While superficial burns covering the epidermis layer, although painful (second-degree), heal within a few weeks without leaving scars, a deep wound takes a long time to heal due to the destruction of the extracellular matrix (ECM) and the degradation of growth factors (GFs), a prolonged inflammatory phase, increases in pro-inflammatory cytokines, proteases, reactive oxygen species (ROS) and possible infection [22]

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Indeed, RNAi knockdown of haao-1 robustly extended lifespan by ~30%, exceeding lifespan extension from either kynu-1(RNAi) or tdo-2(RNAi) (Fig