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Limitations This review synthesizes current knowledge on the epidemiology, mechanisms, risk factors, diagnosis, and management of the three principal mechanistic categories of chronic pain, nociceptive, neuropathic, and nociplastic, and proposes two novel conceptual frameworks: CAP as a multifactorial therapeutic approach and the hippocampus as a putative central sensor for nociplastic pain

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On the other hand, high concentrations of H 2 S are toxic, and there is evidence that H 2 S in high concentration itself causes formation of superoxide by inhibiting mitochondrial oxidative phosphorylation