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Consequently, inhibition of the ErbB pathway using its inhibitor PD158780 normalized mGlu1 receptor signaling, restored dopamine neuron hyperactivity, and alleviated repetitive behaviors, including reduction in self-grooming duration and marble-burying events [57]
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Metabolite profiling was carried out using G6550A Ion Mobility Q-TOF LC/MS (Agilent, Santa Clara, USA) on the Agilent 6,500 Series Q-TOF LC/MS System (version B.05.01, B5125.3), which combines quadrupole and TOF analyzers for high-resolution and accurate mass detection
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