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18 A complex cytokine network operates, where TNF-α induces podocyte apoptosis, IL-6 promotes mesangial proliferation via JAK/STAT3, and MCP-1 recruits monocytes through CCR2
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Instruct patients on the need for folic acid and vitamin B12 supplementation to reduce treatment-related hematologic and gastrointestinal toxicity and of the need for corticosteroids to reduce treatment-related dermatologic toxicity
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