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A minimum 4-fold increase in serum IL-6 was based on prior studies that showed a positive correlation with overall survival in patients treated with tebentafusp, which uses the same anti-CD3 mechanism of action as IMC-M113V 39
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However, the reduced forms of these coenzymes (NADH and NADPH) inhibit the enzyme, decreasing its catalytic activity at 78 and 88% compared with the control, respectively (Wolucka and Van Montagu, 2003)
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