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The canonical pathway is commonly modeled by priming cells with an inflammatory signal such as LPS to induce pro-IL-1β and inflammasome components, followed by an activation signal such as ATP or nigericin to activate NLRP3, ASC speck formation, caspase-1 cleavage, GSDMD cleavage, cytokine release, and pyroptotic membrane rupture
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10.1124/mol.108.048512 13 AudetN.CharfiI.Mnie-FilaliO.AmraeiM.Chabot-DoreA
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