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Indeed, Nrf2 expression can be regulated by SFN, that acting through cytoprotective enzymes with detoxifying and antioxidant action, such as nicotinamide adenine dinucleotide phosphate quinone oxidoreductase 1 (NQO-1), heme oxygenase 1 (HO-1), GSH S-transferase, and thioredoxin reductase, thus counteract the oxidative stress [10]
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