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often stacked with GLP-1 Pyy 2.0 — peptide YY signaling directly reduces appetite at the gut-brain axis Cagri-sema (cagrilintide + semaglutide) — amylin analog + GLP-1 combo with strong satiety data Behavioral Strategies That Survive Food Noise Eat protein first : Protein triggers POMC satiety signaling faster than carbs/fat Sleep 7-8 hours : Sleep deprivation raises ghrelin 15-20% the next day Structured meal timing : Same meal times each day reduces grazing/craving triggers Eliminate food cues : Out of sight, out of mind — this is underrated NAD+ and Metabolic Support Some early evidence suggests NAD+ precursors (NMN, NR) may help with metabolic flexibility and reduce the insulin-resistance signaling that drives cravings