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These include: Nausea (affecting up to 1 in 5 patients) – usually most pronounced during dose escalation and often improves over time [1] [2] Diarrhoea – may be mild to moderate and typically transient Vomiting – less common than nausea but can occur, particularly in the first few weeks Constipation – resulting from slowed gastric emptying Abdominal pain and bloating – often related to delayed gastric emptying Reduced appetite – this is an intended therapeutic effect but can be pronounced The frequency of these side effects tends to be dose-dependent, with higher rates at higher doses

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doi: 10.1177/19322968211026291