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This structure probably enables their reaction with more complex lipid hydroperoxides, but this has been proven only for GPx4 [96,98]
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Since VDUP1 is up-regulated by vitamin D, we may hypothesize that vitamin D may exert beneficial effects against NF1 tumours also by enhancing VDUP1 expression, opening the way to innovative therapeutic strategies in which vitamin D can be used in combination with other drugs, such as HDAC inhibitors, in order to increase VDUP1 expression, in turn promoting cell death of NF1 cancers
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