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In normotensive glaucoma, deletion of the apoptosis signal-regulating kinase 1 ( ASK1 ) gene suppresses the oxidative stress that is linked to glutamate-mediated excitotoxicity, increases survival of RGCs, and reduces the production of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α) by macrophages, microglia, and astrocytes [132,171]
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