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Consider these points: People with Wilson's disease or other copper metabolism disorders are commonly advised to avoid or limit copper peptide exposure Anyone with known sensitivity to copper-containing skincare products Pregnant or breastfeeding individuals, who should always check with a provider before starting new skincare or supplement routines Patients using other active skincare ingredients, since layering products can increase irritation risk For topical cosmetic use, several sources note that systemic copper exposure is expected to be low, and copper toxicity is not a realistic concern at normal cosmetic use levels in otherwise healthy users