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Consistent with the reprotoxic effects of excessive lipolysis, long-term exposure to HFD in mice results in increased lipid droplet accumulation within oocytes and cumulus–oocyte complexes (COCs), reduced mitochondrial membrane potential, upregulated ER stress markers (ATF4, GRP78), and increased apoptosis in granulosa cells, culminating in decreased ovulation and fertilization rates (Wu et al., 2010)
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(PubMed) Dantzer F, Santoro R
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