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Although MP-10 significantly induced early gene expression (c-fos, egr-1, and arc) and activated both D1-and D2-modulated pathways in rodents, confirming target engagement, the behavioral outcomes did not align with therapeutic expectations
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77 Similarly, the RIPK1 inhibitor NST-1s inhibited the expression of necrotic apoptosis-related molecules (RIPK1, RIPK3, and MLKL) in experimental CIA arthritis mice, reducing the number of Th1 and Th17 cells, and increasing the number of Th2 and Treg cells
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