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First studies indicating the implication of the OB in the circadian system reported that bulbectomy slows the rate of re-entrainment to a new LD cycle (i.e., jet-lag protocol), and prevents non-photic entrainment (e.g., social cues) in diurnal rodents 56,57
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According to the data of the China Thalassemia Blue Book (2020), there are about 30 million thalassemia gene carriers and about 300,000 patients with thalassemia major and intermedia in mainland China, and the number of affected people is increasing at a rate of approximately 10% per year
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