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Moreover, genome-wide CRISPR screens further identified LRP8 as essential for ferroptosis resistance by mediating selenocysteine uptake for GPX4 in MYCN -amplified neuroblastoma cells, which rely on LRP8 due to low expression of alternative selenium transporters, highlighting the therapeutic potential of multi-faceted ferroptosis strategies in aggressive neuroblastoma [57]

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We are revising § 414.408 to indicate that payment for these items will be calculated on a lump sum purchase basis and payment under the program will be made in accordance with any frequency limitations established under subpart Q in accordance with section 1834(z)(2) of the Act