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Treatment with recombinant human α-Gal A (rhα-GLA) A previous in vitro study on Fabry disease using mouse aortic endothelial cells from α-Gal A-deficient mice showed that rhα-GLA treatment for 48 hr reduced Gb3 at a dose from 0.1–60 µg/ml 20
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Nevertheless, many clinically relevant conditions of inadequate nutritional Se intake have been identified, which result in the limited performance of functional selenoproteins and enzymes, and thus should be avoided by preventive nutritive measures or treated with adequate supplemental or pharmaceutical Se preparations, when deficiencies are ascertained by proper methods, parameters or biomarkers, and not only on the presumed suspicion of Se imbalance [102]
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