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The modulatory effects of GGT-mediated prooxidant reactions could contribute to the resistance phenotype of GGT-expressing cancer cells by regulating both signal transduction pathways involved in proliferation/apoptosis balance, as well as by inducing protective adaptations in the pool of intracellular antioxidants

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initial, up to 1 hour (first drug billed) CPT 96366: Each additional hour of infusion beyond the first hour CPT 96367: Additional sequential infusion, up to 1 hour (if a second drug is infused after natalizumab) CPT 96368: Concurrent infusion (different drug infused simultaneously) The standard natalizumab infusion runs approximately 1 hour, so most claims pair J2323 with CPT 96365