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Hypoxia at the site of inflammation stimulates FLS to produce messenger RNAs such as CXCL12 and VEGF, resulting in a 50% and 132% increase in the protein levels of VEGF and CXCL12, respectively, after 24 hours of hypoxia (135)
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362 Moreover, HSC quiescence is supported by an abundance of large lysosomes, and maintaining this quiescence requires restrained lysosomal activity
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