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Therefore, despite its promising experimental profile, clinical translation will require well-designed human studies, including pharmacokinetic, dose–response, safety, and drug interaction evaluations
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A decline in stress-induced uptake of serotonin in the hippocampus and prefrontal cortex of mice carrying APOE4 relative to APOE3 is associated with an increase in stress-induced depressive-like behavior (Kim et al., 2023)
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