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Trx in particular has been shown to regulate several signal transduction pathways involving ASK-1, NF-κB, PTEN, and AP-1 and the NLRP-3 inflammasome (41), suggesting that the switch between thiol/disulfide is a critical component of intracellular signaling machinery that turns protein targets on/off to activate or deactivate specific signaling pathways

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[3] Methylcobalamin, the co-enzymatic form of vitamin B₁₂, serves as a cofactor for methionine synthase in one-carbon metabolism and for L-methylmalonyl-CoA mutase in odd-chain fatty-acid oxidation